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Pituitary adenylate cyclase-activating peptide receptor type 1 (PAC1R)

Organism	Rat 1 1. [444] Zhang, W, Duan W, Cheung NS, Huang Z, Shao K, Li QT. 2007. Pituitary adenylate cyclase-activating polypeptide induces translocation of its G-protein-coupled receptor into caveolin-enriched membrane microdomains, leading to enhanced cyclic AMP generation and neurite outgrowth in PC12 cells. J Neurochem. 103:1157-67.
Functional implication	PACAP stimulation induced receptor translocation into lipid raft/caveolae leading to cAMP production and neurite outgrowth 1 1. a. b. [444] Zhang, W, Duan W, Cheung NS, Huang Z, Shao K, Li QT. 2007. Pituitary adenylate cyclase-activating polypeptide induces translocation of its G-protein-coupled receptor into caveolin-enriched membrane microdomains, leading to enhanced cyclic AMP generation and neurite outgrowth in PC12 cells. J Neurochem. 103:1157-67.
Methods used to detect raft association	Detergent-dependent 1; Confocal microscopy 1 1. a. b. c. d. [444] Zhang, W, Duan W, Cheung NS, Huang Z, Shao K, Li QT. 2007. Pituitary adenylate cyclase-activating polypeptide induces translocation of its G-protein-coupled receptor into caveolin-enriched membrane microdomains, leading to enhanced cyclic AMP generation and neurite outgrowth in PC12 cells. J Neurochem. 103:1157-67.
Mechanism of raft association	n.a 1. a. b. c. d. [444] Zhang, W, Duan W, Cheung NS, Huang Z, Shao K, Li QT. 2007. Pituitary adenylate cyclase-activating polypeptide induces translocation of its G-protein-coupled receptor into caveolin-enriched membrane microdomains, leading to enhanced cyclic AMP generation and neurite outgrowth in PC12 cells. J Neurochem. 103:1157-67.
Caveolin-binding motif
Cell type	PC12 cells 1 1. a. b. c. d. e. [444] Zhang, W, Duan W, Cheung NS, Huang Z, Shao K, Li QT. 2007. Pituitary adenylate cyclase-activating polypeptide induces translocation of its G-protein-coupled receptor into caveolin-enriched membrane microdomains, leading to enhanced cyclic AMP generation and neurite outgrowth in PC12 cells. J Neurochem. 103:1157-67.
Species	Rat 1 1. a. b. c. d. e. f. [444] Zhang, W, Duan W, Cheung NS, Huang Z, Shao K, Li QT. 2007. Pituitary adenylate cyclase-activating polypeptide induces translocation of its G-protein-coupled receptor into caveolin-enriched membrane microdomains, leading to enhanced cyclic AMP generation and neurite outgrowth in PC12 cells. J Neurochem. 103:1157-67.
Receptor expression	Endogenous 1 1. a. b. c. d. e. f. g. [444] Zhang, W, Duan W, Cheung NS, Huang Z, Shao K, Li QT. 2007. Pituitary adenylate cyclase-activating polypeptide induces translocation of its G-protein-coupled receptor into caveolin-enriched membrane microdomains, leading to enhanced cyclic AMP generation and neurite outgrowth in PC12 cells. J Neurochem. 103:1157-67.

Refrences

Rat 1

1. a. b. c. d. e. f. [444] Zhang, W, Duan W, Cheung NS, Huang Z, Shao K, Li QT. 2007. Pituitary adenylate cyclase-activating polypeptide induces translocation of its G-protein-coupled receptor into caveolin-enriched membrane microdomains, leading to enhanced cyclic AMP generation and neurite outgrowth in PC12 cells. J Neurochem. 103:1157-67.