M3 muscarinic receptor

Organism	Human 1, 2, 3, Canine 1 1. a. b. [365] Gosens, R, Stelmack GL, Dueck G, Mutawe MM, Hinton M, McNeill KD, Paulson A, Dakshinamurti S, Gerthoffer WT, Thliveris JA et al.. 2007. Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1406-18. 2. [411] Prakash, YS, Thompson MA, Vaa B, Matabdin I, Peterson TE, He T, Pabelick CM. 2007. Caveolins and intracellular calcium regulation in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1118-26. 3. [505] Ekman, M, Rippe C, Sadegh MK, Dabestani S, Mörgelin M, Uvelius B, Swärd K. 2012. Association of muscarinic M₃ receptors and Kir6.1 with caveolae in human detrusor muscle.. European journal of pharmacology. 683(1-3):238-45.
Functional implication	Caveolae disruption by cyclodextrin and caveolin-1 inhibition impairs ca2+ regulation1, 2; M3 muscarinic receptor colocalized with KATP channel subunit Kir6.1 in caveolae 3. 1. a. b. c. [365] Gosens, R, Stelmack GL, Dueck G, Mutawe MM, Hinton M, McNeill KD, Paulson A, Dakshinamurti S, Gerthoffer WT, Thliveris JA et al.. 2007. Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1406-18. 2. a. b. [411] Prakash, YS, Thompson MA, Vaa B, Matabdin I, Peterson TE, He T, Pabelick CM. 2007. Caveolins and intracellular calcium regulation in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1118-26. 3. a. b. [505] Ekman, M, Rippe C, Sadegh MK, Dabestani S, Mörgelin M, Uvelius B, Swärd K. 2012. Association of muscarinic M₃ receptors and Kir6.1 with caveolae in human detrusor muscle.. European journal of pharmacology. 683(1-3):238-45.
Methods used to detect raft association	Disruption of caveolae1, 2; Immunoelectron microscopy 3 1. a. b. c. d. [365] Gosens, R, Stelmack GL, Dueck G, Mutawe MM, Hinton M, McNeill KD, Paulson A, Dakshinamurti S, Gerthoffer WT, Thliveris JA et al.. 2007. Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1406-18. 2. a. b. c. [411] Prakash, YS, Thompson MA, Vaa B, Matabdin I, Peterson TE, He T, Pabelick CM. 2007. Caveolins and intracellular calcium regulation in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1118-26. 3. a. b. c. [505] Ekman, M, Rippe C, Sadegh MK, Dabestani S, Mörgelin M, Uvelius B, Swärd K. 2012. Association of muscarinic M₃ receptors and Kir6.1 with caveolae in human detrusor muscle.. European journal of pharmacology. 683(1-3):238-45.
Mechanism of raft association	n.a 1. a. b. c. d. [365] Gosens, R, Stelmack GL, Dueck G, Mutawe MM, Hinton M, McNeill KD, Paulson A, Dakshinamurti S, Gerthoffer WT, Thliveris JA et al.. 2007. Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1406-18. 2. a. b. c. [411] Prakash, YS, Thompson MA, Vaa B, Matabdin I, Peterson TE, He T, Pabelick CM. 2007. Caveolins and intracellular calcium regulation in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1118-26. 3. a. b. c. [505] Ekman, M, Rippe C, Sadegh MK, Dabestani S, Mörgelin M, Uvelius B, Swärd K. 2012. Association of muscarinic M₃ receptors and Kir6.1 with caveolae in human detrusor muscle.. European journal of pharmacology. 683(1-3):238-45.
Caveolin-binding motif
Cell type	Airway smooth muscle cells 1, 2; Detrusor muscle 4 1. a. b. c. d. e. [365] Gosens, R, Stelmack GL, Dueck G, Mutawe MM, Hinton M, McNeill KD, Paulson A, Dakshinamurti S, Gerthoffer WT, Thliveris JA et al.. 2007. Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1406-18. 2. a. b. c. d. [411] Prakash, YS, Thompson MA, Vaa B, Matabdin I, Peterson TE, He T, Pabelick CM. 2007. Caveolins and intracellular calcium regulation in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1118-26. 3. a. b. c. [505] Ekman, M, Rippe C, Sadegh MK, Dabestani S, Mörgelin M, Uvelius B, Swärd K. 2012. Association of muscarinic M₃ receptors and Kir6.1 with caveolae in human detrusor muscle.. European journal of pharmacology. 683(1-3):238-45. 4. [502] Bogard, AS, Adris P, Ostrom RS. 2012. Adenylyl cyclase 2 selectively couples to E prostanoid type 2 receptors, whereas adenylyl cyclase 3 is not receptor-regulated in airway smooth muscle.. The Journal of pharmacology and experimental therapeutics. 342(2):586-95.
Species	Human 1, 2, 3; Canine 1 1. a. b. c. d. e. f. g. [365] Gosens, R, Stelmack GL, Dueck G, Mutawe MM, Hinton M, McNeill KD, Paulson A, Dakshinamurti S, Gerthoffer WT, Thliveris JA et al.. 2007. Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1406-18. 2. a. b. c. d. e. [411] Prakash, YS, Thompson MA, Vaa B, Matabdin I, Peterson TE, He T, Pabelick CM. 2007. Caveolins and intracellular calcium regulation in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1118-26. 3. a. b. c. d. [505] Ekman, M, Rippe C, Sadegh MK, Dabestani S, Mörgelin M, Uvelius B, Swärd K. 2012. Association of muscarinic M₃ receptors and Kir6.1 with caveolae in human detrusor muscle.. European journal of pharmacology. 683(1-3):238-45. 4. [502] Bogard, AS, Adris P, Ostrom RS. 2012. Adenylyl cyclase 2 selectively couples to E prostanoid type 2 receptors, whereas adenylyl cyclase 3 is not receptor-regulated in airway smooth muscle.. The Journal of pharmacology and experimental therapeutics. 342(2):586-95.
Receptor expression	Endogenous 1, 2, 3 1. a. b. c. d. e. f. g. h. [365] Gosens, R, Stelmack GL, Dueck G, Mutawe MM, Hinton M, McNeill KD, Paulson A, Dakshinamurti S, Gerthoffer WT, Thliveris JA et al.. 2007. Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1406-18. 2. a. b. c. d. e. f. [411] Prakash, YS, Thompson MA, Vaa B, Matabdin I, Peterson TE, He T, Pabelick CM. 2007. Caveolins and intracellular calcium regulation in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1118-26. 3. a. b. c. d. e. [505] Ekman, M, Rippe C, Sadegh MK, Dabestani S, Mörgelin M, Uvelius B, Swärd K. 2012. Association of muscarinic M₃ receptors and Kir6.1 with caveolae in human detrusor muscle.. European journal of pharmacology. 683(1-3):238-45. 4. [502] Bogard, AS, Adris P, Ostrom RS. 2012. Adenylyl cyclase 2 selectively couples to E prostanoid type 2 receptors, whereas adenylyl cyclase 3 is not receptor-regulated in airway smooth muscle.. The Journal of pharmacology and experimental therapeutics. 342(2):586-95.

Refrences

Human 1, 2, 3; Canine 1

1. a. b. c. d. e. f. g. [365] Gosens, R, Stelmack GL, Dueck G, Mutawe MM, Hinton M, McNeill KD, Paulson A, Dakshinamurti S, Gerthoffer WT, Thliveris JA et al.. 2007. Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1406-18.
2. a. b. c. d. e. [411] Prakash, YS, Thompson MA, Vaa B, Matabdin I, Peterson TE, He T, Pabelick CM. 2007. Caveolins and intracellular calcium regulation in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 293:L1118-26.
3. a. b. c. d. [505] Ekman, M, Rippe C, Sadegh MK, Dabestani S, Mörgelin M, Uvelius B, Swärd K. 2012. Association of muscarinic M₃ receptors and Kir6.1 with caveolae in human detrusor muscle.. European journal of pharmacology. 683(1-3):238-45.
4. [502] Bogard, AS, Adris P, Ostrom RS. 2012. Adenylyl cyclase 2 selectively couples to E prostanoid type 2 receptors, whereas adenylyl cyclase 3 is not receptor-regulated in airway smooth muscle.. The Journal of pharmacology and experimental therapeutics. 342(2):586-95.

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M3 muscarinic receptor