Dopamine D1 receptor

Organism	Human 1, 2; Rat 3 1. [443] Yu, P, Yang Z, Jones JE, Wang Z, Owens SA, Mueller SC, Felder RA, Jose PA. 2004. D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Kidney Int. 66:2167-80. 2. [381] Kong, MM, Hasbi A, Mattocks M, Fan T, O'Dowd BF, George SR. 2007. Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1. Mol Pharmacol. 72:1157-70. 3. [471] Trivedi, M, Narkar VA, Hussain T, Lokhandwala MF. 2004. Dopamine recruits D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules.. American journal of physiology. Renal physiology. 287(5):F921-31.
Functional implication	Agonist treatment causes the receptor shift to caveolar plasma membrane 1, 2, 3; Caveolin-2 antisense reduces cAMP accumulation 1; Caveolin-1 binding motif mutation and MβCD treatment abolish receptor internalization 2 1. a. b. c. [443] Yu, P, Yang Z, Jones JE, Wang Z, Owens SA, Mueller SC, Felder RA, Jose PA. 2004. D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Kidney Int. 66:2167-80. 2. a. b. c. [381] Kong, MM, Hasbi A, Mattocks M, Fan T, O'Dowd BF, George SR. 2007. Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1. Mol Pharmacol. 72:1157-70. 3. a. b. [471] Trivedi, M, Narkar VA, Hussain T, Lokhandwala MF. 2004. Dopamine recruits D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules.. American journal of physiology. Renal physiology. 287(5):F921-31.
Methods used to detect raft association	Detergent-free 1, 2, 3; Confocal microscopy 1; Bioluminescence Resonance Energy Transfer (BRET) 2 1. a. b. c. d. e. [443] Yu, P, Yang Z, Jones JE, Wang Z, Owens SA, Mueller SC, Felder RA, Jose PA. 2004. D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Kidney Int. 66:2167-80. 2. a. b. c. d. e. [381] Kong, MM, Hasbi A, Mattocks M, Fan T, O'Dowd BF, George SR. 2007. Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1. Mol Pharmacol. 72:1157-70. 3. a. b. c. [471] Trivedi, M, Narkar VA, Hussain T, Lokhandwala MF. 2004. Dopamine recruits D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules.. American journal of physiology. Renal physiology. 287(5):F921-31.
Mechanism of raft association	Interaction with caveolin 1; Bound caveolin-1 2 1. a. b. c. d. e. f. [443] Yu, P, Yang Z, Jones JE, Wang Z, Owens SA, Mueller SC, Felder RA, Jose PA. 2004. D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Kidney Int. 66:2167-80. 2. a. b. c. d. e. f. [381] Kong, MM, Hasbi A, Mattocks M, Fan T, O'Dowd BF, George SR. 2007. Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1. Mol Pharmacol. 72:1157-70. 3. a. b. c. [471] Trivedi, M, Narkar VA, Hussain T, Lokhandwala MF. 2004. Dopamine recruits D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules.. American journal of physiology. Renal physiology. 287(5):F921-31.
Caveolin-binding motif	Yes 2 1. a. b. c. d. e. f. [443] Yu, P, Yang Z, Jones JE, Wang Z, Owens SA, Mueller SC, Felder RA, Jose PA. 2004. D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Kidney Int. 66:2167-80. 2. a. b. c. d. e. f. g. [381] Kong, MM, Hasbi A, Mattocks M, Fan T, O'Dowd BF, George SR. 2007. Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1. Mol Pharmacol. 72:1157-70. 3. a. b. c. [471] Trivedi, M, Narkar VA, Hussain T, Lokhandwala MF. 2004. Dopamine recruits D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules.. American journal of physiology. Renal physiology. 287(5):F921-31.
Cell type	HEK-293 1; Proximal tubular cells 1,3; COS-7 cells 2 1. a. b. c. d. e. f. g. h. [443] Yu, P, Yang Z, Jones JE, Wang Z, Owens SA, Mueller SC, Felder RA, Jose PA. 2004. D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Kidney Int. 66:2167-80. 2. a. b. c. d. e. f. g. h. [381] Kong, MM, Hasbi A, Mattocks M, Fan T, O'Dowd BF, George SR. 2007. Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1. Mol Pharmacol. 72:1157-70. 3. a. b. c. d. [471] Trivedi, M, Narkar VA, Hussain T, Lokhandwala MF. 2004. Dopamine recruits D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules.. American journal of physiology. Renal physiology. 287(5):F921-31.
Species	Human 1, 2; Monkey 2; Rat 3 1. a. b. c. d. e. f. g. h. i. [443] Yu, P, Yang Z, Jones JE, Wang Z, Owens SA, Mueller SC, Felder RA, Jose PA. 2004. D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Kidney Int. 66:2167-80. 2. a. b. c. d. e. f. g. h. i. j. [381] Kong, MM, Hasbi A, Mattocks M, Fan T, O'Dowd BF, George SR. 2007. Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1. Mol Pharmacol. 72:1157-70. 3. a. b. c. d. e. [471] Trivedi, M, Narkar VA, Hussain T, Lokhandwala MF. 2004. Dopamine recruits D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules.. American journal of physiology. Renal physiology. 287(5):F921-31.
Receptor expression	Stable transfection 1; COS-7: Transient transfection 2; Endogenous 3 1. a. b. c. d. e. f. g. h. i. j. [443] Yu, P, Yang Z, Jones JE, Wang Z, Owens SA, Mueller SC, Felder RA, Jose PA. 2004. D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Kidney Int. 66:2167-80. 2. a. b. c. d. e. f. g. h. i. j. k. [381] Kong, MM, Hasbi A, Mattocks M, Fan T, O'Dowd BF, George SR. 2007. Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1. Mol Pharmacol. 72:1157-70. 3. a. b. c. d. e. f. [471] Trivedi, M, Narkar VA, Hussain T, Lokhandwala MF. 2004. Dopamine recruits D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules.. American journal of physiology. Renal physiology. 287(5):F921-31.

Refrences

Human 1, 2; Monkey 2; Rat 3

1. a. b. c. d. e. f. g. h. i. [443] Yu, P, Yang Z, Jones JE, Wang Z, Owens SA, Mueller SC, Felder RA, Jose PA. 2004. D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Kidney Int. 66:2167-80.
2. a. b. c. d. e. f. g. h. i. j. [381] Kong, MM, Hasbi A, Mattocks M, Fan T, O'Dowd BF, George SR. 2007. Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1. Mol Pharmacol. 72:1157-70.
3. a. b. c. d. e. [471] Trivedi, M, Narkar VA, Hussain T, Lokhandwala MF. 2004. Dopamine recruits D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules.. American journal of physiology. Renal physiology. 287(5):F921-31.

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Dopamine D1 receptor