β3a-adrenoreceptor

Organism	Mouse 1, 2 1. [422] Sato, M, Hutchinson DS, Evans BA, Summers RJ. 2007. Functional domains of the mouse beta(3)-adrenoceptor associated with differential G-protein coupling. Biochem Soc Trans. 35:1035-7. 2. [504] Sato, M, Hutchinson DS, Halls ML, Furness SGB, Bengtsson T, Evans BA, Summers RJ. 2012. Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor.. The Journal of biological chemistry. 287(24):20674-88.
Functional implication	Filipin treatment alters accumulation of c-AMP 1; Filipin III treatment, caveolin-1 knockdown and caveolin-binding motif mutation of receptor promote pertussis toxin (PTX) sensivity of the receptor which indicating Gαi/0 coupling. It is suggested that receptor interaction with caveolin inhibits coupling to Gαi/0 proteins 2. . 1. a. b. [422] Sato, M, Hutchinson DS, Evans BA, Summers RJ. 2007. Functional domains of the mouse beta(3)-adrenoceptor associated with differential G-protein coupling. Biochem Soc Trans. 35:1035-7. 2. a. b. [504] Sato, M, Hutchinson DS, Halls ML, Furness SGB, Bengtsson T, Evans BA, Summers RJ. 2012. Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor.. The Journal of biological chemistry. 287(24):20674-88.
Methods used to detect raft association	Caveolae disruption 1, 2; In situ proximity assay 2 1. a. b. c. [422] Sato, M, Hutchinson DS, Evans BA, Summers RJ. 2007. Functional domains of the mouse beta(3)-adrenoceptor associated with differential G-protein coupling. Biochem Soc Trans. 35:1035-7. 2. a. b. c. d. [504] Sato, M, Hutchinson DS, Halls ML, Furness SGB, Bengtsson T, Evans BA, Summers RJ. 2012. Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor.. The Journal of biological chemistry. 287(24):20674-88.
Mechanism of raft association	Putative caveolin binding domain 1 1. a. b. c. d. [422] Sato, M, Hutchinson DS, Evans BA, Summers RJ. 2007. Functional domains of the mouse beta(3)-adrenoceptor associated with differential G-protein coupling. Biochem Soc Trans. 35:1035-7. 2. a. b. c. d. [504] Sato, M, Hutchinson DS, Halls ML, Furness SGB, Bengtsson T, Evans BA, Summers RJ. 2012. Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor.. The Journal of biological chemistry. 287(24):20674-88.
Caveolin-binding motif	Yes 1 1. a. b. c. d. e. [422] Sato, M, Hutchinson DS, Evans BA, Summers RJ. 2007. Functional domains of the mouse beta(3)-adrenoceptor associated with differential G-protein coupling. Biochem Soc Trans. 35:1035-7. 2. a. b. c. d. [504] Sato, M, Hutchinson DS, Halls ML, Furness SGB, Bengtsson T, Evans BA, Summers RJ. 2012. Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor.. The Journal of biological chemistry. 287(24):20674-88.
Cell type	CHO-K1 1, 2, Brown adipocytes 1, 2 1. a. b. c. d. e. f. g. [422] Sato, M, Hutchinson DS, Evans BA, Summers RJ. 2007. Functional domains of the mouse beta(3)-adrenoceptor associated with differential G-protein coupling. Biochem Soc Trans. 35:1035-7. 2. a. b. c. d. e. f. [504] Sato, M, Hutchinson DS, Halls ML, Furness SGB, Bengtsson T, Evans BA, Summers RJ. 2012. Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor.. The Journal of biological chemistry. 287(24):20674-88.
Species	Hamster 1 2; Mouse 1, 2 1. a. b. c. d. e. f. g. h. i. [422] Sato, M, Hutchinson DS, Evans BA, Summers RJ. 2007. Functional domains of the mouse beta(3)-adrenoceptor associated with differential G-protein coupling. Biochem Soc Trans. 35:1035-7. 2. a. b. c. d. e. f. g. h. [504] Sato, M, Hutchinson DS, Halls ML, Furness SGB, Bengtsson T, Evans BA, Summers RJ. 2012. Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor.. The Journal of biological chemistry. 287(24):20674-88.
Receptor expression	Endogenous 1, 2; Transient transfection 2 1. a. b. c. d. e. f. g. h. i. j. [422] Sato, M, Hutchinson DS, Evans BA, Summers RJ. 2007. Functional domains of the mouse beta(3)-adrenoceptor associated with differential G-protein coupling. Biochem Soc Trans. 35:1035-7. 2. a. b. c. d. e. f. g. h. i. j. [504] Sato, M, Hutchinson DS, Halls ML, Furness SGB, Bengtsson T, Evans BA, Summers RJ. 2012. Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor.. The Journal of biological chemistry. 287(24):20674-88.

Refrences

Hamster 1 2; Mouse 1, 2

1. a. b. c. d. e. f. g. h. i. [422] Sato, M, Hutchinson DS, Evans BA, Summers RJ. 2007. Functional domains of the mouse beta(3)-adrenoceptor associated with differential G-protein coupling. Biochem Soc Trans. 35:1035-7.
2. a. b. c. d. e. f. g. h. [504] Sato, M, Hutchinson DS, Halls ML, Furness SGB, Bengtsson T, Evans BA, Summers RJ. 2012. Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor.. The Journal of biological chemistry. 287(24):20674-88.

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β3a-adrenoreceptor